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Table 1 Comparison of relevant clinical indicators affecting the surgical efficacy in children [n (%)]

From: Surgical outcomes of drug-refractory infantile epileptic spasms syndrome and related prognostic factors: a retrospective study

Influencing factor

Effective group

(n = 22)

Less effective group

(n = 8)

χ2

P-value

OR (95%CI)

Sex

  

0.455

0.396

 

 Male

14 (63.6)

4 (50.0)

  

1.00

 Female

8 (36.4)

4 (50.0)

  

1.75 (0.34–8.98)

Age at seizure onset

  

0.341

0.452

 

 < 6 months

14 (63.6)

6 (75.0)

  

1.00

 6 months–1 year

8 (36.4)

2 (25.0)

  

0.58 (0.09–3.60)

Age at surgery

  

2.744

0.108

 

 < 1 year

10 (45.5)

1 (12.5)

  

1.00

 > 1 year

12 (54.5)

7 (87.5)

  

5.83 (0.61–55.74)

Seizure duration

  

4.224

0.047

 

 Within 1 year

12 (54.5)

1 (12.5)

  

1.00

 Over 1 year

10 (45.5)

7 (87.5)

  

8.40 (0.88–80.27)

Etiology

  

5.408

0.020*

 

 Innate structure

17 (77.3)

4 (50.0)

   

 Acquired structure

5 (22.7)

1 (12.5)

  

-

 Heredity

0 (0.0)

3 (37.5)

   

Seizure type

  

2.078

0.161

 

 Epileptic spasm

5 (22.7)

4 (50.0)

  

1.00

 Combined with other types of seizure

17 (77.3)

4 (50.0)

  

0.29 (0.05–1.62)

MRI

  

0.545

0.405

 

 Positive

19 (86.4)

6 (75.0)

  

1.00

 Negative

3 (13.6)

2 (25.0)

  

2.11 (0.28–15.77)

PET-MRI

  

5.514

0.048

 

 Positive

21 (95.5)

5 (62.5)

  

1.00

 Negative

1 (4.5)

3 (37.5)

  

12.6 (1.07–148.13)

Surgery type

  

3.996

0.046*

 

 Hemispherectomy

10 (45.5)

3 (37.5)

  

-

 One lobe/multilobar resection

12 (54.5)

1 (12.5)

   

 Palliative operation

0 (0.0)

4 (50.0)

   

Lesion location

  

12.692

0.003

 

 Focal/unilaterality

22 (84.6)

4 (15.4)

  

1.00

 Bilateral

0 (0.0)

4 (15.4)

  

0.15 (0.06–0.38)

  1. *Linear trend testing, palliative surgery (including stereotactic radiofrequency thermocoagulation or corpus callosotomy)
  2. CI confidence interval, MRI magnetic resonance imaging, OR odds ratio, PET positron emission tomograph