Skip to main content

Table 2 Number of instrumental variables and associated phenotypic variance

From: Impulsivity and epilepsy: a bidirectional mendelian randomization study

Exposure

Outcome

Number of SNPs

R 2

Mean F (Min, Max)

IAF

EWRS

48

0.50

16.25 (13.86, 22.99)

ICF

EWRS

36

0.41

17.60 (15.17, 21.26)

IPF

EWRS

35

0.32

14.33 (12.12, 18.22)

IA-NGTA

EWRS

45

0.55

18.56 (15.88, 25.65)

IA-GTA

EWRS

57

0.67

17.64 (15.27, 22.79)

DRD

EWRS

40

0.48

18.52 (16.33, 22.06)

DRD-SMR

EWRS

34

0.39

17.77 (15.51, 22.74)

DRD-MMR

EWRS

40

0.45

17.35 (15.17, 22.54)

DRD-LMR

EWRS

41

0.48

17.96 (15.50, 23.76)

Negative urgency

EWRS

34

0.42

19.20 (16.78, 24.46)

Lack of perseverance

EWRS

41

0.49

18.52 (16.20, 23.75)

Lack of premeditation

EWRS

40

0.49

19.17 (15.77, 26.44)

Positive urgency

EWRS

40

0.49

18.90 (15.98, 24.81)

Sensation seeking

EWRS

35

0.44

19.33 (16.81, 25.23)

EWRS

IAF

8

0.03

1443.27 (1356.41, 1569.39)

EWRS

ICF

13

0.05

1462.62 (1369.72, 1669.24)

EWRS

IPF

13

0.05

1444.14 (1363.59, 1634.59)

EWRS

IA-NGTA

7

0.03

1483.92 (1363.59, 1613.57)

EWRS

IA-GTA

9

0.03

1529.20 (1383.33, 2010.72)

EWRS

DRD

10

0.04

1470.89 (1392.86, 1669.24)

EWRS

DRD-SMR

11

0.04

1537.79 (1369.72, 2052.16)

EWRS

DRD-MMR

10

0.04

1537.36 (1369.72, 2052.16)

EWRS

DRD-LMR

11

0.04

1519.80 (1392.86, 2052.16)

EWRS

Negative urgency

12

0.04

1490.17 (1363.59, 1930.68)

EWRS

Lack of perseverance

11

0.04

1442.50 (1363.59, 1582.68)

EWRS

Lack of premeditation

4

0.01

1390.28 (1363.59, 1434.94)

EWRS

Positive urgency

12

0.04

1494.70 (1363.59, 1634.59)

EWRS

Sensation seeking

11

0.04

1500.58 (1363.59, 1779.39)

  1. IAF Impulsive action factor, ICF Impulsive choice factor, IPF Impulsive personality factor, IA-NGTA Impulsive action with No-Go trial accuracy, IA-GTA Impulsive action with Go trial accuracy, DRD Delayed reward discounting, DRD-SMR Delayed reward discounting with small magnitude rewards, DRD-MMR Delayed reward discounting with medium magnitude rewards, DRD-LMR Delayed reward discounting with large magnitude rewards, EWRS Epilepsy with recurrent seizure