Table 1 The positive rate of liver damage and blood coagulation in short term VPA initial treatment group and long term (over 2 years) VPA monotherapy group (%)
From: The safety of valproic acid treatment in children with epilepsy: a retrospective real-world research
Adverse drug reactions | Short term treatment | Long term monotherapy | P-value | |
|---|---|---|---|---|
30–90 days | 90–180 days | |||
Liver damage (tests) | 5 (26.32) | 4 (22.22) | 39 (14.44) | 0.224 |
Abnormal blood coagulation function | 1 (4.00) | 0 (0.00) | 0 (0.00) | 0.166 |
Diagnosed liver damage | 0 (0.00) | 1 (1.92) | 4 (0.54) | 0.293 |
Diagnosed nasal bleeding | 1 (1.75) | 1 (1.92) | 14 (1.89) | 0.218 |