Table 4 Laboratory data before and after long-term VPA monotherapy treatment (%)
From: The safety of valproic acid treatment in children with epilepsy: a retrospective real-world research
Laboratory items | Baseline (%) | During treatment (%) | P-value |
|---|---|---|---|
ALT > 40 IU/L | 3 (2.2) | 4 (1.9) | 1.000 |
AST > 40 IU/L | 14 (10.3) | 27 (12.9) | 0.471 |
Serum ammonia > 72 μmol/L | 5 (5.2) | 10 (11.9) | 0.105 |
Serum sodium < 135 mmol/L | 3 (3.0) | 6 (6.3) | 0.324 |
Serum calcium < 2.2 mmol/L | 8 (7.2) | 12 (11.7) | 0.265 |
25-(OH)-VitD < 30 ng/ml | 21 (87.5) | 15 (55.6) | 0.012* |
PLT < 150 × 109/L | 4 (2.5) | 11 (4.4) | 0.305 |