Fig. 1

Schematic diagram of purine nucleotide anabolism. Red boxes in bold indicate substances that produce toxic effects on the nervous system. Abbreviations: A, Adenosine; ADSL, Adenylosuccinate lyase; AIR, Aminoimidazole ribotide; AICAR, Aminoimidazolecarboxamide ribose; AICAR TF, Amino imidazole carboxamide ribosidetransformylase; AMP, Adenosine monophosphate; ADP, Adenosine diphosphate; ATP, Adenosine triphosphate; ATIC, Amino imidazole carboxamide ribosidetransformylase/I inosine monophosphorus cyclohydrolase; CAIR, Carboxyl amino imidazoleribotide; FAICAR, Formylaminoimidazole-carbamide ribose; FGAM, Formyl glycin amidine ribotide; FGAR, Formyl glycin amide ribotide; G, Guanine; GAR, Glycinamide ribotide; GMP, Guanine monophosphate; GDP, Guanine diphosphate; GTP, Guanine triphosphate; HGPRT, Hypoxanthine–guanine phosphoribosyl transferase; I, Inosine; IMP, Inosine monophosphate; IMP CH, Inosine mono phosphorus cyclohydrolase; PRPP, Phosphoribosyl pyrophosphate; PRA, Phosphoribosyl amine; SAICAR, Succinylaminoimidazolecarboxamide ribose; S-AMP, Adenylosuccinate; XMP, Xanthosine monophosphate