Fig. 3

Gene expression profiles related to morphometric similarity (MSN) differences between mesial temporal lobe epilepsy (mTLE) with and without hippocampal sclerosis (HS). a Difference in MSN between mTLE with and without HS, along with the weighted gene expression map of the PLS1 score in the left hemisphere. b The scatter plot of the HS-non-HS t-value in MSN (y-axis) and the PLS1 score, showing Pearson’s r₍₁₅₀₎ = 0.50, P_spin = 0.001. c The PLS1 loading and significance in the 28 overlapped genes. (* in SMAD3 represents significance before FDR correction). Significance was noted in PRR5 and IRF3 after FDR correction. d Scatter plot of the PRR5 (positive weighted) gene expression (x-axis) versus the HS-non-HS t-value (y-axis). e Scatter plot of IRF3 (negative weighted) gene expression (x-axis) and the HS-non-HS t-value(y-axis)